A Single Nonsteroidal Anti-Inflammatory Drugs-Induced Anaphylaxis to Diclofenac Confirmed by Skin Testing

Abstract

Anaphylaxis is a serious acute systemic allergic reaction that can lead to death, thus requiring immediate diagnosis and treatment. In particular, food is the most common cause of anaphylaxis in children, adolescents, and young adults. In addition to physical contact with food, anaphylaxis can also be induced by exposures other than ingestion, such as the inhalation of aerosolized food proteins. Korean males undergo medical screening prior to a compulsory military service. A history of possible food allergy requires referral to a specialized allergy clinic. It was reported in 2021 that a 19-year-old male patient enlisted in the military was referred to the allergy clinic for an oral provocation test. That case confirmed that anaphylaxis was caused not only by walnut intake, but also by skin contact or by inhaling walnut particles, which will be reviewed in this paper.